Bile Duct Cancer

Common Symptoms:

• Jaundice (yellow skin)
• Itchiness all over your body
• Light-coloured stools or dark yellow urine
• Abdomen pain
• Appetite loss or weight loss
• Nausea or vomiting
• Fever

Imaging:

Basic imaging methods for hepatobiliary tumours are

• Ultrasonography,
• Computed Tomography (CT) and
• Magnetic Resonance Imaging (MRI)

Further methods include endosonography, cholangiography (endoscopic or percutaneous), positron emission tomography (PET), cholescintigraphy and angiography

Tumour markers:

Serum tumour markers linked to bile duct carcinomas are

• carcino-embryogenic antigen (CEA) and
• carbohydrate antigen CA 19-9.

The latter has for values above 100 U/mL a sensitivity of 75 % and specifi city of 80 %.

Treatment:

Bile duct cancer treatment in Kolkata can be curative (with intent to cure, aiming for long term survival) or palliative (aiming to prolong survival and/or improve life quality and postpone disease symptoms). The only standard curative option is the complete surgical resection.

Unfortunately, most patients (nearly 90% according to some authors) are not candidates for curative treatment. It is usually for unresectable advanced/metastatic tumour. Some patients are not capable of radical surgery due to their performance status. In these and other cases that sadly form the majority of clinical situations, palliative care is the option.

Preoperative treatments :

• Biliary drainage: Preoperative biliary drainage has proved to be beneficial in the presence of cholangitis, severe malnutrition, and coagulation abnormalities, and it is absolutely indicated for patients requiring major hepatic resection for curative surgery.
• Prolonged preoperative jaundice is associated with increased postoperative morbidity and mortality after hepatic resection due to severe cholestatic liver dysfunction.
• Portal vein embolization: Hilar cholangiocarcinoma usually requires extended hepatectomy (i.e. extended right hepatectomy, and right or left trisegmentectomy), which is related with a rather high rate of perioperative mortality (0% to 19%). This is partly due to the increased rate of postoperative liver failure with major hepatic resection. Portal vein embolization, which was first indicated for hilar cholangiocarcinoma by Makuuchi et al, is now widely accepted as a valuable preoperative measure in anticipation of extensive liver resection with a subsequent small liver remnant volume. Compensatory hypertrophy of the remnant liver parenchyma, usually an increase of 8% to 20% within 2 to 6 wk, is induced in association with atrophy of the future resected liver by selectively occluding the main portal branch to the liver parenchyma to be removed. In general, portal vein embolization can benefit patients requiring a future liver remnant volume of less than 25% to 35% of the original liver volume.

Surgical Management (Resectable Tumours):

• Pancreaticoduodenectomy (Whipple’s PD) coupled with porta hepatis lymphadenectomy, is the standard treatment of choice for the complete removal of distal bile duct cancer.
• Extended hepatectomy for hilar cholangiocarcinoma Based on the mode of tumor extension and the radicality and simplicity of the procedure, extended right- or left hemihepatectomy is regarded as the standard radical operation for hilar cholangiocarcinoma.
• Liver transplantation for hilar cholangiocarcinoma For the treatment of locally advanced hilar cholangiocarcinoma beyond the indication for resection, orthotopic liver transplantation (OLT) may offer the advantage of resection of all structures involved by the tumor, including vessels within the hepatoduodenal ligament, all intraand extrahepatic bile ducts, and whole liver parenchyma.

Prognostic factors and markers:

Prognostic factors are the

• Completeness of resection,
• Lymph node involvement and
• Tumour diff erentiation.

Dr. Purnendu Bhowmik, one of the best bile duct cancer treatment doctors in Kolkata, says that these factors influence the long-term survival of the patient.