Gallbladder cancer (GBC) is a rare but well-known disease that kills people of different races and places. In India, GBC is most common in the northern and northeastern provinces of Uttar Pradesh, Bihar, Orissa, West Bengal and Assam, says the best gallbladder cancer treatment doctor associated with our clinic in Kolkata. It is twice as common in women as in men and is the most common digestive cancer in women in northern India. Apart from gallstones, female gender, race, genetic predisposition and lifestyle are factors that are associated with risks in the development of GBC. According to Dr. Purnendu Bhowmik, considered to be the best gallbladder laparoscopic surgeon in Kolkata, symptoms of presentation are unclear and are similar to other diseases such as cholelithiasis and cholecystitis. No chemical tests were more important at the initial diagnosis. Elevated bilirubin is a sign of advanced disease. Tumor symptoms – CEA and CA 19-9 do not play a major role in the diagnosis as this is not specified by GBC. Various imaging tools available include Ultrasound (USG), Computer Tomographic (CT) scanning, and Magnetic Resonance Imaging (MRI) with Magnetic Resonance Cholangiopancreatography (MRCP) and Magnetic Resonance Angiography (MRA). Among the worst predictions namely the 5% survival rate at GBC, completing the surgical provision (R0) is the only hope for long-term survival. The best gallbladder cancer treatment in Kolkata involves surgical management of GBC (extended cholecystectomy) and is influenced by the mode of transmission of GBC to the liver, lymphatic and vascular invasion; direct dissemination of affected organs and intraperitoneal seeding and luminal through the cystic duct (intraductal).